Spend It Wisely

Case

Brook runs the Saltmarsh trial of Velquor for heart failure, and you are the unblinded statistician on its data monitoring committee.

What this scene will ask

Group sequential trial with Lan-DeMets O'Brien-Fleming type alpha spending, three interim looks at stated information fractions, and observed z statistics.

Planned flag: look at which the trial stops; nominal z boundary at that look, 3 dp; cumulative alpha spent, 4 dp.

Status

[#] Sealed. This scene opens when it is written and passes review. Nothing on CTFEpi expires, so there is no rush.